› 5a6r

X-ray diffraction
2.85Å resolution

Crystal structure of the BTB domain of human KCTD17

Released:
DOI: 10.2210/pdb5a6r/pdb
PDB entry 5a6r coloured by chain, front view.
PDB entry 5a6r coloured by chain, side view.
PDB entry 5a6r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Pinkas DM, Sanvitale CE, Bufton JC, Sorrell FJ, Solcan N, Chalk R, Doutch J, Bullock AN
Biochem J 474 3747-3761 (2017)
PMID: 28963344

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185412 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BTB/POZ domain-containing protein KCTD17 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 135 amino acids
Theoretical weight: 15.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8N5Z5 (Residues: 13-124; Coverage: 36%)
Gene name: KCTD17
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: F432
Unit cell:
a: 285.743Å b: 285.743Å c: 285.743Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.242
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders.
Teng et al. (2019)
7 more

5 mentions without citation

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Pinkas et al. (2017)
4 more