› 5aaq

Solution NMR

TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy

Released:
DOI: 10.2210/pdb5aaq/pdb
PDB entry 5aaq coloured by chain, ensemble of 20 models, front view.
PDB entry 5aaq coloured by chain, ensemble of 20 models, side view.
PDB entry 5aaq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.
Thurston TL, Boyle KB, Allen M, Ravenhill BJ, Karpiyevich M, Bloor S, Kaul A, Noad J, Foeglein A, Matthews SA, Komander D, Bycroft M, Randow F
EMBO J 35 1779-92 (2016)
PMID: 27370208

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-binding and coiled-coil domain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 6.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13137 (Residues: 388-446; Coverage: 13%)
Gene names: CALCOCO2, NDP52

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: CNS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

25 review citations

Molecular definitions of autophagy and related processes.
Galluzzi et al. (2017)
24 more

1 mention without citation

Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.
Thurston et al. (2016)