› 5b73

X-ray diffraction
1.8Å resolution

Crystal structure of human ZMYND8 PHD-Bromo-PWWP domain

Released:
DOI: 10.2210/pdb5b73/pdb
PDB entry 5b73 coloured by chain, front view.
PDB entry 5b73 coloured by chain, side view.
PDB entry 5b73 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.
Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, Zhu G, Chen TY, Dhar SS, Kan PY, Wang Z, Shiekhattar R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG
Mol Cell 63 470-84 (2016)
PMID: 27477906

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193930 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MYND-type zinc finger-containing chromatin reader ZMYND8 Chain: A
Molecule details ›
Chain: A
Length: 339 amino acids
Theoretical weight: 39.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ULU4 (Residues: 73-406; Coverage: 28%)
Gene names: KIAA1125, PRKCBP1, RACK7, ZMYND8
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 67.083Å b: 67.999Å c: 70.309Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.224
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Ali et al. (2018)
20 more

3 mentions without citation

Atypical histone targets of PHD fingers.
Black et al. (2023)
2 more