› 5bw2

X-ray diffraction
2.27Å resolution

X-ray crystal structure of Aplysia californica acetylcholine binding protein (Ac-AChBP) Y55W in complex with 2-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octane; 2-(3-pyridyl)quinuclidine; 2-PQ (TI-4699)

Released:
DOI: 10.2210/pdb5bw2/pdb
Model geometry
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PDB entry 5bw2 coloured by chain, front view.
PDB entry 5bw2 coloured by chain, side view.
PDB entry 5bw2 coloured by chain, top view.
Source organism: Aplysia californica
Entry authors: Bobango J, Sankaran B, Park JF, Wu J, Talley TT

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186694 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 230 amino acids
Theoretical weight: 26.24 KDa
Source organism: Aplysia californica
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WSF8 (Residues: 18-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

1 bound ligand:
Ligand 4VU 4 x 4VU
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 163.74Å b: 84.4Å c: 119.66Å
α: 90° β: 130.8° γ: 90°
R-values:
R R work R free
0.186 0.184 0.222
Expression system: Homo sapiens

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