› 5bx1

X-ray diffraction
1.9Å resolution

Crystal Structure of PRL-1 complex with compound analogy 3

Released:
DOI: 10.2210/pdb5bx1/pdb
PDB entry 5bx1 coloured by chain, front view.
PDB entry 5bx1 coloured by chain, side view.
PDB entry 5bx1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Liu S, Bai Y, Zhang Z

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-187984 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein tyrosine phosphatase type IVA 1 Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 18.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q93096 (Residues: 4-160; Coverage: 91%)
Gene names: PRL1, PTP4A1, PTPCAAX1
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:
Ligand 4XA 1 x 4XA
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2221
Unit cell:
a: 47.07Å b: 76.471Å c: 86.873Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.24
Expression system: Escherichia coli

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