› 5c02

X-ray diffraction
1.59Å resolution

Influenza A M2 transmembrane domain drug-resistant S31N mutant at pH 8.0

Released:
DOI: 10.2210/pdb5c02/pdb
PDB entry 5c02 coloured by chain, front view.
PDB entry 5c02 coloured by chain, side view.
PDB entry 5c02 coloured by chain, top view.
Source organism: Influenza A virus (A/Udorn/307/1972(H3N2))
Primary publication:
Crystal structure of the drug-resistant S31N influenza M2 proton channel.
Thomaston JL, DeGrado WF
Protein Sci 25 1551-4 (2016)
PMID: 27082171

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 2.78 KDa
Source organism: Influenza A virus (A/Udorn/307/1972(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P0DOF5 (Residues: 22-46; Coverage: 26%)
Gene name: M

Ligands and Environments

4 bound ligands:
Ligand SR 1 x SR
Ligand CL 2 x CL
Ligand CA 1 x CA
Ligand OLC 2 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: I4
Unit cell:
a: 28.65Å b: 28.65Å c: 68.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.163 0.16 0.197
Expression system: Not provided

Quick links

Citations

4 review citations

Drug resistance in influenza A virus: the epidemiology and management.
Hussain et al. (2017)
3 more

4 mentions without citation

Put a cork in it: Plugging the M2 viral ion channel to sink influenza.
Jalily et al. (2020)
3 more