› 5c9n

X-ray diffraction
2.2Å resolution

Crystal structure of GEMC1 coiled-coil domain

Released:
DOI: 10.2210/pdb5c9n/pdb
PDB entry 5c9n coloured by chain, front view.
PDB entry 5c9n coloured by chain, side view.
PDB entry 5c9n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.
Caillat C, Fish A, Pefani DE, Taraviras S, Lygerou Z, Perrakis A
Acta Crystallogr D Biol Crystallogr 71 2278-86 (2015)
PMID: 26527144

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Geminin coiled-coil domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 85 amino acids
Theoretical weight: 10.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A6NCL1 (Residues: 64-148; Coverage: 25%)
Gene names: GEMC1, GMNC

Ligands and Environments

1 bound ligand:
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 50.035Å b: 70.574Å c: 83.055Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.223 0.249
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Regulation of the initiation of DNA replication in human cells.
Moiseeva et al. (2018)
2 more

2 mentions without citation

ARCIMBOLDO on coiled coils.
Caballero et al. (2018)
1 more