Function and Biology Details
Reaction catalysed:
(1a) [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [RBR-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [RBR-type E3 ubiquitin transferase]-S-ubiquitinyl-L-cysteine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- E3 ubiquitin-protein ligase parkin
- IBR domain
- E3 ubiquitin-protein ligase parkin, Rcat domain
- E3 ubiquitin-protein ligase parkin, BRcat domain
- E3 ubiquitin-protein ligase parkin, RING finger, HC subclass
- TRIAD supradomain
- RING/Ubox-like zinc-binding domain
- E3 ubiquitin ligase RBR family
1 more domain
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
E3 ubiquitin-protein ligase parkin (preferred)
PDBe Complex ID:
PDB-CPX-129926 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase parkin
Molecule details ›
Chain: A
Length: 330 amino acids
Theoretical weight: 36.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
Sequence domains:
Length: 330 amino acids
Theoretical weight: 36.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
- Canonical:
O60260 (Residues: 137-465; Coverage: 71%)
Sequence domains:
