› 5ce9

X-ray diffraction
1.8Å resolution

structure of tyrosinase from walnut (Juglans regia)

Released:
DOI: 10.2210/pdb5ce9/pdb
PDB entry 5ce9 coloured by chain, front view.
PDB entry 5ce9 coloured by chain, side view.
PDB entry 5ce9 coloured by chain, top view.
Source organism: Juglans regia
Primary publication:
The Structure of a Plant Tyrosinase from Walnut Leaves Reveals the Importance of "Substrate-Guiding Residues" for Enzymatic Specificity.
Bijelic A, Pretzler M, Molitor C, Zekiri F, Rompel A
Angew Chem Int Ed Engl 54 14677-80 (2015)
PMID: 26473311

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111021 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosinase copper-binding domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 38.41 KDa
Source organism: Juglans regia
UniProt:
  • Canonical: C0LU17 (Residues: 101-439; Coverage: 56%)
Gene name: PPO1
Sequence domains:
Structure domains: Di-copper center containing domain from catechol oxidase

Ligands and Environments

3 bound ligands:
Ligand CU 4 x CU
Ligand O 2 x O
Ligand NA 7 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: C2
Unit cell:
a: 115.43Å b: 90.94Å c: 86.58Å
α: 90° β: 130.18° γ: 90°
R-values:
R R work R free
0.171 0.17 0.188

Quick links

Citations

2 review citations

Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins.
Lai et al. (2018)
1 more

17 mentions without citation

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors.
Pillaiyar et al. (2017)
16 more