Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(4) + 2-oxoglutarate + O(2) = a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + succinate + formaldehyde + CO(2)
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Lysine-specific demethylase 5A and peptide (preferred)
PDBe Complex ID:
PDB-CPX-151439 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lysine-specific demethylase 5A
Molecule details ›
Chain: A
Length: 790 amino acids
Theoretical weight: 90.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 790 amino acids
Theoretical weight: 90.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P29375 (Residues: 12-797; Coverage: 47%)
Sequence domains:
- jmjN domain
- ARID/BRIGHT DNA binding domain
- PHD-finger
- JmjC domain, hydroxylase
- Lysine-specific demethylase 5, C-terminal helical domain
- C5HC2 zinc finger
