› 5cek

X-ray diffraction
2.8Å resolution

Pseudokinase domain of Human Tribbles Homolog 1

Released:
DOI: 10.2210/pdb5cek/pdb
PDB entry 5cek coloured by chain, front view.
PDB entry 5cek coloured by chain, side view.
PDB entry 5cek coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase.
Murphy JM, Nakatani Y, Jamieson SA, Dai W, Lucet IS, Mace PD
Structure 23 2111-21 (2015)
PMID: 26455797

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188745 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tribbles homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RU8 (Residues: 83-343; Coverage: 70%)
Gene names: C8FW, GIG2, TRB1, TRIB1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P6222
Unit cell:
a: 152.693Å b: 152.693Å c: 62.798Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.207 0.246
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.
Eyers et al. (2017)
20 more

5 mentions without citation

Prospects for pharmacological targeting of pseudokinases.
Kung et al. (2019)
4 more