› 5cgn

X-ray diffraction
2.2Å resolution

Structure of quasiracemic Ala-Magainin 2 with a beta amino acid substitution at position 8

Released:
DOI: 10.2210/pdb5cgn/pdb
PDB entry 5cgn coloured by chain, front view.
PDB entry 5cgn coloured by chain, side view.
PDB entry 5cgn coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif.
Hayouka Z, Thomas NC, Mortenson DE, Satyshur KA, Weisblum B, Forest KT, Gellman SH
J Am Chem Soc 137 11884-7 (2015)
PMID: 26369301

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145628 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Magainin-2 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 23 amino acids
Theoretical weight: 2.52 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P11006 (Residues: 267-289; Coverage: 8%)
Gene name: magainins
D-Ala-Magainin Derivative Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 23 amino acids
Theoretical weight: 2.49 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
11 modified residues:
Ligand DIL 8 x DIL
Ligand DLY 16 x DLY
Ligand DPN 12 x DPN
Ligand DLE 4 x DLE
Ligand DHI 4 x DHI
Ligand DAL 20 x DAL
Ligand DVA 4 x DVA
Ligand DGL 4 x DGL
Ligand MED 4 x MED
Ligand DSG 4 x DSG
Ligand DSE 4 x DSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21212
Unit cell:
a: 56.69Å b: 56.69Å c: 51.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.182 0.247
Expression system: Not provided

Quick links

Citations

8 citation in other articles

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril.
Tayeb-Fligelman et al. (2017)
7 more

1 mention without citation

Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif.
Hayouka et al. (2015)