› 5cgo

X-ray diffraction
1.5Å resolution

Structure of quasiracemic Ala-Magainin 2 with a beta amino acid substitution at position 13

Released:
DOI: 10.2210/pdb5cgo/pdb
PDB entry 5cgo coloured by chain, front view.
PDB entry 5cgo coloured by chain, side view.
PDB entry 5cgo coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif.
Hayouka Z, Thomas NC, Mortenson DE, Satyshur KA, Weisblum B, Forest KT, Gellman SH
J Am Chem Soc 137 11884-7 (2015)
PMID: 26369301

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145627 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Magainin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 23 amino acids
Theoretical weight: 2.52 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P11006 (Residues: 267-289; Coverage: 8%)
Gene name: magainins
D-Ala-Magainin 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 23 amino acids
Theoretical weight: 2.49 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
11 modified residues:
Ligand DIL 4 x DIL
Ligand DLY 8 x DLY
Ligand DPN 6 x DPN
Ligand DLE 2 x DLE
Ligand DHI 2 x DHI
Ligand DAL 10 x DAL
Ligand DVA 2 x DVA
Ligand DGL 2 x DGL
Ligand MED 2 x MED
Ligand DSG 2 x DSG
Ligand DSE 2 x DSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P1
Unit cell:
a: 24.85Å b: 27Å c: 29.96Å
α: 109.76° β: 102.35° γ: 90.23°
R-values:
R R work R free
0.175 0.172 0.239
Expression system: Not provided

Quick links

Citations

8 citation in other articles

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril.
Tayeb-Fligelman et al. (2017)
7 more

2 mentions without citation

Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif.
Hayouka et al. (2015)
1 more