› 5ci9

X-ray diffraction
2.3Å resolution

Crystal structure of human Tob in complex with inhibitor fragment 6

Released:
DOI: 10.2210/pdb5ci9/pdb
PDB entry 5ci9 coloured by chain, front view.
PDB entry 5ci9 coloured by chain, side view.
PDB entry 5ci9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach.
Bai Y, Tashiro S, Nagatoishi S, Suzuki T, Yan D, Liu R, Tsumoto K, Bartlam M, Yamamoto T
Protein Cell 6 924-8 (2015)
PMID: 26518565

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156241 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Tob1 Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 38.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P50616 (Residues: 1-345; Coverage: 100%)
Gene names: TOB, TOB1, TROB1
Sequence domains: BTG family
Structure domains: Anti-proliferative protein, N-terminal domain

Ligands and Environments

2 bound ligands:
Ligand 549 2 x 549
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P6122
Unit cell:
a: 65.119Å b: 65.119Å c: 162.945Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.214 0.264
Expression system: Escherichia coli BL21

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