› 5cmm

X-ray diffraction
1.27Å resolution

Crystal structure of the GluK2EM LBD dimer assembly complex with 2S,4R-4-methylglutamate

Released:
DOI: 10.2210/pdb5cmm/pdb
PDB entry 5cmm coloured by chain, front view.
PDB entry 5cmm coloured by chain, side view.
PDB entry 5cmm coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of kainate subtype glutamate receptor desensitization.
Meyerson JR, Chittori S, Merk A, Rao P, Han TH, Serpe M, Mayer ML, Subramaniam S
Nature 537 567-571 (2016)
PMID: 27580033

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chain: A
Molecule details ›
Chain: A
Length: 259 amino acids
Theoretical weight: 29.36 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: Q13002 (Residues: 429-493, 667-806; Coverage: 23%)
  • Canonical: P42260 (Residues: 494-544; Coverage: 6%)
Gene names: GLUR6, GRIK2, Glur6, Grik2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand SYM 1 x SYM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P61
Unit cell:
a: 52.308Å b: 52.308Å c: 170.923Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.144 0.143 0.163
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert.
Reiner et al. (2018)
13 more

1 mention without citation

Structural basis of kainate subtype glutamate receptor desensitization.
Meyerson et al. (2016)