› 5cs9

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor alpha chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 183 amino acids
Theoretical weight: 21.17 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii CBS 7435
UniProt:
  • Canonical: P14210 (Residues: 28-210; Coverage: 26%)
Gene names: HGF, HPTA
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MES 1 x MES
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 53.286Å b: 64.152Å c: 57.199Å
α: 90° β: 94.96° γ: 90°
R-values:
R R work R free
0.215 0.213 0.251
Expression system: Komagataella phaffii CBS 7435

Quick links

Citations

5 citation in other articles

Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH.
Singh et al. (2019)
4 more

2 mentions without citation

State of the structure address on MET receptor activation by HGF.
Linossi et al. (2021)
1 more