› 5d7v

X-ray diffraction
2.33Å resolution

Crystal structure of PTK6 kinase domain

Released:
DOI: 10.2210/pdb5d7v/pdb
PDB entry 5d7v coloured by chain, front view.
PDB entry 5d7v coloured by chain, side view.
PDB entry 5d7v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution.
Thakur MK, Kumar A, Birudukota S, Swaminathan S, Tyagi R, Gosu R
Biochem Biophys Res Commun 478 637-42 (2016)
PMID: 27480927

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-tyrosine kinase 6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 269 amino acids
Theoretical weight: 31.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13882 (Residues: 185-446; Coverage: 58%)
Gene names: BRK, PTK6
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PO4 4 x PO4
Ligand GOL 12 x GOL
1 modified residue:
Ligand CXM 4 x CXM

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P1
Unit cell:
a: 49.718Å b: 76.308Å c: 87.271Å
α: 81.46° β: 75.92° γ: 74.93°
R-values:
R R work R free
0.222 0.219 0.282
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Targeting protein tyrosine kinase 6 in cancer.
Gilic et al. (2020)
1 other article

2 mentions without citation

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
Qiu et al. (2018)
1 more