› 5d9k

X-ray diffraction
2.55Å resolution

Rsk2 N-terminal Kinase in Complex with BI-D1870

Released:
DOI: 10.2210/pdb5d9k/pdb
PDB entry 5d9k coloured by chain, front view.
PDB entry 5d9k coloured by chain, side view.
PDB entry 5d9k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
Jain R, Mathur M, Lan J, Costales A, Atallah G, Ramurthy S, Subramanian S, Setti L, Feucht P, Warne B, Doyle L, Basham S, Jefferson AB, Lindvall M, Appleton BA, Shafer CM
J Med Chem 58 6766-83 (2015)
PMID: 26270416

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156422 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 330 amino acids
Theoretical weight: 37.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P51812 (Residues: 39-366; Coverage: 44%)
Gene names: ISPK1, MAPKAPK1B, RPS6KA3, RSK2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand 584 2 x 584
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 34.19Å b: 53.71Å c: 207.94Å
α: 90° β: 91.75° γ: 90°
R-values:
R R work R free
0.183 0.181 0.227
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges.
Gaestel M. (2015)
3 more

4 mentions without citation

Therapeutic targeting of p90 ribosomal S6 kinase.
Wright et al. (2023)
3 more