› 5ddl

X-ray diffraction
1.98Å resolution

Crystal Structure of WT Human Glutathione Transferase Pi soaked with a metalloid then back-soaked with glutathione

Released:
DOI: 10.2210/pdb5ddl/pdb
PDB entry 5ddl coloured by chain, front view.
PDB entry 5ddl coloured by chain, side view.
PDB entry 5ddl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Parker LJ, Parker MW, Morton CJ

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140593 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase P Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09211 (Residues: 1-210; Coverage: 100%)
Gene names: FAEES3, GST3, GSTP1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand 5AU 2 x 5AU

Cofactor: Ligand GSH 2 x GSH
3 bound ligands:
Ligand MES 2 x MES
Ligand SO4 1 x SO4
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: C2
Unit cell:
a: 77.665Å b: 89.795Å c: 68.854Å
α: 90° β: 98.08° γ: 90°
R-values:
R R work R free
0.14 0.138 0.178
Expression system: Escherichia coli

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