› 5dsd

X-ray diffraction
2.31Å resolution

The crystal structure of the C-terminal domain of Ebola (Bundibugyo) nucleoprotein

Released:
DOI: 10.2210/pdb5dsd/pdb
PDB entry 5dsd coloured by chain, front view.
PDB entry 5dsd coloured by chain, side view.
PDB entry 5dsd coloured by chain, top view.
Source organism: Bundibugyo ebolavirus
Primary publication:
Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses.
Baker LE, Ellena JF, Handing KB, Derewenda U, Utepbergenov D, Engel DA, Derewenda ZS
Acta Crystallogr D Struct Biol 72 49-58 (2016)
PMID: 26894534

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-110765 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 12.27 KDa
Source organism: Bundibugyo ebolavirus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: B8XCM7 (Residues: 641-739; Coverage: 13%)
Gene names: DF49_53413gpNP, DH33_45404gpNP, NP

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P6422
Unit cell:
a: 108.957Å b: 108.957Å c: 82.736Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.168 0.202
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

The lifecycle of the Ebola virus in host cells.
Yu et al. (2017)
2 more

3 mentions without citation

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis.
Xu et al. (2017)
2 more