› 5du1

X-ray diffraction
1.8Å resolution

Crystal structure of Dendroaspis polylepis mambalgin-1 wild-type in P21 space group.

Released:
DOI: 10.2210/pdb5du1/pdb
PDB entry 5du1 coloured by chain, front view.
PDB entry 5du1 coloured by chain, side view.
PDB entry 5du1 coloured by chain, top view.
Source organism: Dendroaspis polylepis polylepis
Primary publication:
Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.
Mourier G, Salinas M, Kessler P, Stura EA, Leblanc M, Tepshi L, Besson T, Diochot S, Baron A, Douguet D, Lingueglia E, Servent D
J Biol Chem 291 2616-29 (2016)
PMID: 26680001

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mambalgin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 57 amino acids
Theoretical weight: 6.57 KDa
Source organism: Dendroaspis polylepis polylepis
UniProt:
  • Canonical: P0DKR6 (Residues: 22-78; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P21
Unit cell:
a: 39.03Å b: 50.24Å c: 46.88Å
α: 90° β: 93.38° γ: 90°
R-values:
R R work R free
0.177 0.174 0.224

Quick links

Citations

14 review citations

Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms.
Cristofori-Armstrong et al. (2017)
13 more

5 mentions without citation

Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels.
Osmakov et al. (2020)
4 more