› 5dzn

X-ray diffraction
2.3Å resolution

human T-cell immunoglobulin and mucin domain protein 4

Released:
DOI: 10.2210/pdb5dzn/pdb
PDB entry 5dzn coloured by chain, front view.
PDB entry 5dzn coloured by chain, side view.
PDB entry 5dzn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope.
Yuan S, Cao L, Ling H, Dang M, Sun Y, Zhang X, Chen Y, Zhang L, Su D, Wang X, Rao Z
Protein Cell 6 814-24 (2015)
PMID: 26487564

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188526 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell immunoglobulin and mucin domain-containing protein 4 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 114 amino acids
Theoretical weight: 12.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96H15 (Residues: 22-134; Coverage: 31%)
Gene names: TIM4, TIMD4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 100.4Å b: 107.297Å c: 115.649Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.238
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry.
Martin et al. (2016)
5 more

2 mentions without citation

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry.
Rhein et al. (2016)
1 more