› 5dzo

X-ray diffraction
1.3Å resolution

Crystal structure of human T-cell immunoglobulin and mucin domain protein 1

Released:
DOI: 10.2210/pdb5dzo/pdb
PDB entry 5dzo coloured by chain, front view.
PDB entry 5dzo coloured by chain, side view.
PDB entry 5dzo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope.
Yuan S, Cao L, Ling H, Dang M, Sun Y, Zhang X, Chen Y, Zhang L, Su D, Wang X, Rao Z
Protein Cell 6 814-24 (2015)
PMID: 26487564

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188427 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatitis A virus cellular receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 11.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96D42 (Residues: 22-127; Coverage: 31%)
Gene names: HAVCR1, KIM1, TIM1, TIMD1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NO3 2 x NO3
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P43212
Unit cell:
a: 50.739Å b: 50.739Å c: 84.162Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.156 0.176
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry.
Martin et al. (2016)
5 more

8 mentions without citation

Kidney injury molecule-1 is a potential receptor for SARS-CoV-2.
Yang et al. (2021)
7 more