› 5e2x

X-ray diffraction
2.1Å resolution

The crystal structure of the C-terminal domain of Ebola (Tai Forest) nucleoprotein

Released:
DOI: 10.2210/pdb5e2x/pdb
PDB entry 5e2x coloured by chain, front view.
PDB entry 5e2x coloured by chain, side view.
PDB entry 5e2x coloured by chain, top view.
Source organism: Tai Forest ebolavirus
Primary publication:
Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses.
Baker LE, Ellena JF, Handing KB, Derewenda U, Utepbergenov D, Engel DA, Derewenda ZS
Acta Crystallogr D Struct Biol 72 49-58 (2016)
PMID: 26894534

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-110773 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 101 amino acids
Theoretical weight: 12.17 KDa
Source organism: Tai Forest ebolavirus
Expression system: Escherichia coli
UniProt:
  • Canonical: B8XCN6 (Residues: 641-739; Coverage: 13%)
Gene names: DF49_53414gpNP, NP

Ligands and Environments

1 bound ligand:
Ligand 2PE 4 x 2PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 57.847Å b: 60.075Å c: 73.547Å
α: 69.15° β: 68.93° γ: 89.93°
R-values:
R R work R free
0.195 0.191 0.26
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The lifecycle of the Ebola virus in host cells.
Yu et al. (2017)
2 more

3 mentions without citation

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis.
Xu et al. (2017)
2 more