5e6q

X-ray diffraction
2.3Å resolution

Importin alpha binding to XRCC1 NLS peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-148465 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1 Chain: B
Molecule details ›
Chain: B
Length: 510 amino acids
Theoretical weight: 55.33 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 70-529; Coverage: 87%)
Gene names: Kpna2, Rch1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
DNA repair protein XRCC1 Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 4.02 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P18887 (Residues: 241-276; Coverage: 6%)
Gene name: XRCC1

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 78.668Å b: 90.112Å c: 100.699Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.174 0.208
Expression systems:
  • Escherichia coli
  • Not provided