› 5e7x

X-ray diffraction
1.8Å resolution

Ligand binding domain 1 of Penicillium marneffei MP1 protein in complex with palmitic acid

Released:
DOI: 10.2210/pdb5e7x/pdb
PDB entry 5e7x coloured by chain, front view.
PDB entry 5e7x coloured by chain, side view.
PDB entry 5e7x coloured by chain, top view.
Source organism: Talaromyces marneffei PM1
Primary publication:
Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts.
Lam WH, Sze KH, Ke Y, Tse MK, Zhang H, Woo PCY, Lau SKP, Lau CCY, Xu S, Lai PM, Zhou T, Antonyuk SV, Kao RYT, Yuen KY, Hao Q
Infect Immun 87 (2019)
PMID: 30670555

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108649 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell wall antigen Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 16.37 KDa
Source organism: Talaromyces marneffei PM1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A8HBN5 (Residues: 8-162; Coverage: 85%)
Gene name: MP1
Sequence domains: Hydrophobic surface binding protein A

Ligands and Environments

3 bound ligands:
Ligand PLM 1 x PLM
Ligand ACT 1 x ACT
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P43
Unit cell:
a: 52.58Å b: 52.58Å c: 57.69Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms.
Pruksaphon et al. (2022)
2 more

2 mentions without citation

Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts.
Lam et al. (2019)
1 more