› 5eg9

X-ray diffraction
2.3Å resolution

The cap binding site of influenza virus protein PB2 as a drug target

Released:
DOI: 10.2210/pdb5eg9/pdb
PDB entry 5eg9 coloured by chain, front view.
PDB entry 5eg9 coloured by chain, side view.
PDB entry 5eg9 coloured by chain, top view.
Source organism: Influenza A virus (A/Ck/HK/YU22/2002(H5N1))
Primary publication:
The cap-binding site of influenza virus protein PB2 as a drug target.
Severin C, Rocha de Moura T, Liu Y, Li K, Zheng X, Luo M
Acta Crystallogr D Struct Biol 72 245-53 (2016)
PMID: 26894672

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179537 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase basic protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 183 amino acids
Theoretical weight: 20.5 KDa
Source organism: Influenza A virus (A/Ck/HK/YU22/2002(H5N1))
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6DNL8 (Residues: 318-420, 428-483; Coverage: 21%)
Gene name: PB2
Sequence domains: Influenza RNA polymerase PB2 CAP binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 37.133Å b: 109.01Å c: 39.655Å
α: 90° β: 90.54° γ: 90°
R-values:
R R work R free
0.194 0.191 0.258
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design.
Stevaert et al. (2016)
3 more