› 5egi

X-ray diffraction
3.3Å resolution

Structure of a Trimeric Intracellular Cation channel from C. elegans with bound Ca2+

Released:
DOI: 10.2210/pdb5egi/pdb
PDB entry 5egi coloured by chain, front view.
PDB entry 5egi coloured by chain, side view.
PDB entry 5egi coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Pore architecture of TRIC channels and insights into their gating mechanism.
Yang H, Hu M, Guo J, Ou X, Cai T, Liu Z
Nature 538 537-541 (2016)
PMID: 27698420

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192409 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trimeric intracellular cation channel type 1B.1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 257 amino acids
Theoretical weight: 28.84 KDa
Source organism: Caenorhabditis elegans
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: Q9NA75 (Residues: 1-251; Coverage: 85%)
Gene names: Y57A10A.10, tric-1B.1
Sequence domains: TRIC channel

Ligands and Environments

3 bound ligands:
Ligand PT5 3 x PT5
Ligand CA 1 x CA
Ligand DMU 1 x DMU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-1A
Spacegroup: P41212
Unit cell:
a: 102.05Å b: 102.05Å c: 279.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.263 0.263 0.272
Expression system: Komagataella phaffii GS115

Quick links

Citations

7 review citations

Voltage-Sensing Phosphatases: Biophysics, Physiology, and Molecular Engineering.
Okamura et al. (2018)
6 more

4 mentions without citation

Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.
Muller et al. (2019)
3 more