› 5eme

X-ray diffraction
1.15Å resolution

Complex of RNA r(GCAGCAGC) with antisense PNA p(CTGCTGC)

Released:
DOI: 10.2210/pdb5eme/pdb
PDB entry 5eme coloured by chain, front view.
PDB entry 5eme coloured by chain, side view.
PDB entry 5eme coloured by chain, top view.
Source organisms:
Primary publication:
The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches--toward anti-sense therapy against TREDs.
Kiliszek A, Banaszak K, Dauter Z, Rypniewski W
Nucleic Acids Res 44 1937-43 (2016)
PMID: 26717983

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196924 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecules (2 distinct):
RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 8 nucleotides
Theoretical weight: 2.56 KDa
Source organism: Homo sapiens
Expression system: Not provided
Chain: B
Details unavailable


Molecule type: peptide nucleic acid
Chain: B
Length: 8 moieties
Theoretical weight: 2.19 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P3121
Unit cell:
a: 35.171Å b: 35.171Å c: 68.918Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.141 0.139 0.177
Expression system: Not provided

Quick links

Citations

3 review citations

Peptide nucleic acids: Advanced tools for biomedical applications.
Gupta et al. (2017)
2 more

5 mentions without citation

Antibacterial Peptide Nucleic Acids-Facts and Perspectives.
Wojciechowska et al. (2020)
4 more