› 5erd

X-ray diffraction
2.9Å resolution

Crystal structure of human Desmoglein-2 ectodomain

Released:
DOI: 10.2210/pdb5erd/pdb
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PDB entry 5erd coloured by chain, front view.
PDB entry 5erd coloured by chain, side view.
PDB entry 5erd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of adhesive binding by desmocollins and desmogleins.
Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L
Proc Natl Acad Sci U S A 113 7160-5 (2016)
PMID: 27298358

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171926 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Desmoglein-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 559 amino acids
Theoretical weight: 62.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14126 (Residues: 50-602; Coverage: 51%)
Gene names: CDHF5, DSG2
Sequence domains: Cadherin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand NAG 3 x NAG
Ligand MAN 6 x MAN
Ligand CA 22 x CA
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 90.968Å b: 114.476Å c: 226.127Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.241 0.287
Expression system: Homo sapiens

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Citations

37 review citations

Pemphigus.
Kasperkiewicz et al. (2017)
36 more

15 mentions without citation

Structural basis of adhesive binding by desmocollins and desmogleins.
Harrison et al. (2016)
14 more

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