› 5erj

X-ray diffraction
1.45Å resolution

X-ray structure of cisplatin-encapsulated horse spleen apoferritin

Released:
DOI: 10.2210/pdb5erj/pdb
PDB entry 5erj coloured by chain, front view.
PDB entry 5erj coloured by chain, side view.
PDB entry 5erj coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Cisplatin encapsulation within a ferritin nanocage: a high-resolution crystallographic study.
Pontillo N, Pane F, Messori L, Amoresano A, Merlino A
Chem Commun (Camb) 52 4136-9 (2016)
PMID: 26888424

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136237 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin light chain Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 19.87 KDa
Source organism: Equus caballus
UniProt:
  • Canonical: P02791 (Residues: 2-175; Coverage: 99%)
Gene name: FTL
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

5 bound ligands:
Ligand CL 4 x CL
Ligand CD 13 x CD
Ligand CPT 1 x CPT
Ligand GOL 1 x GOL
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: F432
Unit cell:
a: 180.899Å b: 180.899Å c: 180.899Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.147 0.145 0.173

Quick links

Citations

6 review citations

Recent trends in protein and peptide-based biomaterials for advanced drug delivery.
Varanko et al. (2020)
5 more

2 mentions without citation

Cryo-EM single-particle structure refinement and map calculation using Servalcat.
Yamashita et al. (2021)
1 more