› 5f1c

X-ray diffraction
2.9Å resolution

Crystal structure of an invertebrate P2X receptor from the Gulf Coast tick in the presence of ATP and Zn2+ ion at 2.9 Angstroms

Released:
DOI: 10.2210/pdb5f1c/pdb
PDB entry 5f1c coloured by chain, front view.
PDB entry 5f1c coloured by chain, side view.
PDB entry 5f1c coloured by chain, top view.
Source organism: Amblyomma maculatum
Primary publication:
Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels.
Kasuya G, Fujiwara Y, Takemoto M, Dohmae N, Nakada-Nakura Y, Ishitani R, Hattori M, Nureki O
Cell Rep 14 932-944 (2016)
PMID: 26804916

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124365 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP receptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 358 amino acids
Theoretical weight: 40.18 KDa
Source organism: Amblyomma maculatum
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: G3MM57 (Residues: 24-376; Coverage: 92%)
Sequence domains: ATP P2X receptor
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 5 x NAG
Ligand ZN 13 x ZN
Ligand ATP 3 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 82.458Å b: 139.9Å c: 202.015Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.255 0.289
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

The P2X7 Receptor in Infection and Inflammation.
Di Virgilio et al. (2017)
5 more

5 mentions without citation

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30.
Illes et al. (2021)
4 more