› 5f96

X-ray diffraction
2.24Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207309 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein Chain: G
Molecule details ›
Chain: G
Length: 353 amino acids
Theoretical weight: 39.21 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0M3KKW9 (Residues: 1-353; Coverage: 100%)
Gene name: HIV-1 Env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
HEAVY CHAIN OF ANTIBODY CH235.12 Chain: H
Molecule details ›
Chain: H
Length: 225 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
LIGHT CHAIN OF ANTIBODY CH235.12 Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 12 x NAG
Ligand EPE 3 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 53.659Å b: 69.869Å c: 127.272Å
α: 90° β: 94.61° γ: 90°
R-values:
R R work R free
0.192 0.19 0.233
Expression system: Homo sapiens

Quick links

Citations

53 review citations

Germinal Center B Cell Dynamics.
Mesin et al. (2016)
52 more

7 mentions without citation

Polyvalent vaccine approaches to combat HIV-1 diversity.
Korber et al. (2017)
6 more