› 5f9w

X-ray diffraction
2.89Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-229620 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein Chains: A, G
Molecule details ›
Chains: A, G
Length: 353 amino acids
Theoretical weight: 39.21 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A0M3KKW9 (Residues: 1-353; Coverage: 100%)
Gene name: HIV-1 Env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
Heavy chain of CH235-lineage antibody CH235 Chains: B, H
Molecule details ›
Chains: B, H
Length: 225 amino acids
Theoretical weight: 24.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Light chain of CH235-lineage antibody CH235 Chains: C, L
Molecule details ›
Chains: C, L
Length: 213 amino acids
Theoretical weight: 23.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 27 x NAG
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P32
Unit cell:
a: 123.429Å b: 123.429Å c: 127.332Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.18 0.232
Expression system: Homo sapiens

Quick links

Citations

55 review citations

Germinal Center B Cell Dynamics.
Mesin et al. (2016)
54 more

5 mentions without citation

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Bonsignori et al. (2016)
4 more