› 5fb7

X-ray diffraction
1.5Å resolution

Ligand binding domain 2 of Penicillium marneffei MP1 protein complexed with multiple arachidonic acids

Released:
DOI: 10.2210/pdb5fb7/pdb
PDB entry 5fb7 coloured by chain, front view.
PDB entry 5fb7 coloured by chain, side view.
PDB entry 5fb7 coloured by chain, top view.
Source organism: Talaromyces marneffei PM1
Primary publication:
Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response.
Sze KH, Lam WH, Zhang H, Ke YH, Tse MK, Woo PCY, Lau SKP, Lau CCY, Cai JP, Tung ETK, Lo RKC, Xu S, Kao RYT, Hao Q, Yuen KY
Cell Chem Biol 24 182-194 (2017)
PMID: 28111099

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-100713 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 155 amino acids
Theoretical weight: 16.6 KDa
Source organism: Talaromyces marneffei PM1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A093VKV7 (Residues: 188-342; Coverage: 36%)
Gene name: GQ26_0022220
Sequence domains: Hydrophobic surface binding protein A

Ligands and Environments

1 bound ligand:
Ligand ACD 8 x ACD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 59.239Å b: 98.495Å c: 100.12Å
α: 90° β: 90.01° γ: 90°
R-values:
R R work R free
0.192 0.191 0.217
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms.
Pruksaphon et al. (2022)
2 more

2 mentions without citation

Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts.
Lam et al. (2019)
1 more