› 5fg6

X-ray diffraction
1.1Å resolution

Crystal structure of the bromodomain of human BRD1 (BRPF2) in complex with OF-1 chemical probe

Released:
DOI: 10.2210/pdb5fg6/pdb
PDB entry 5fg6 coloured by chain, front view.
PDB entry 5fg6 coloured by chain, side view.
PDB entry 5fg6 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Owen DR, Gerstenberger BS, Savitsky P, Chaikuad A, Fedorov O, Nunez-Alonso G, Filippakopoulos P, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Muller S, Knapp S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95696 (Residues: 563-688; Coverage: 12%)
Gene names: BRD1, BRL, BRPF2
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

4 bound ligands:
Ligand EDO 4 x EDO
Ligand 5XE 1 x 5XE
Ligand NI 1 x NI
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2221
Unit cell:
a: 70.771Å b: 84.328Å c: 52.08Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.197
Expression system: Escherichia coli

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