Function and Biology Details
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA clamp superfamily
- DNA polymerase III, beta sliding clamp
- Exonuclease, RNase T/DNA polymerase III
- DNA polymerase 3, epsilon subunit
- DNA polymerase III, beta sliding clamp, C-terminal
- DNA polymerase III, beta sliding clamp, central
- DNA polymerase III, beta sliding clamp, N-terminal
- Error-prone DNA polymerase/DNA polymerase III subunit alpha DnaE/PolC
12 more domains
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-118681 (preferred)
Entry contents:
3 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (5 distinct):
DNA polymerase III subunit alpha
Molecule details ›
Beta sliding clamp
Molecule details ›
Chains: B, C
Length: 366 amino acids
Theoretical weight: 40.63 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 366 amino acids
Theoretical weight: 40.63 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P0A988 (Residues: 1-366; Coverage: 100%)
Sequence domains:
DNA polymerase III subunit epsilon
Molecule details ›
Chain: D
Length: 243 amino acids
Theoretical weight: 27.12 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Exonuclease
Length: 243 amino acids
Theoretical weight: 27.12 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P03007 (Residues: 1-243; Coverage: 100%)
Sequence domains: Exonuclease
