› 5fto

X-ray diffraction
2.22Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALK tyrosine kinase receptor Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 35.33 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UM73 (Residues: 1094-1407; Coverage: 20%)
Gene name: ALK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand YMX 1 x YMX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 52.435Å b: 58.471Å c: 105.089Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.257
Expression system: Spodoptera frugiperda

Quick links

Citations

49 review citations

NTRK fusion-positive cancers and TRK inhibitor therapy.
Cocco et al. (2018)
48 more

10 mentions without citation

An overview of kinase downregulators and recent advances in discovery approaches.
Wang et al. (2021)
9 more