› 5fzt

X-ray diffraction
2.1Å resolution

The crystal structure of R7R8 in complex with a DLC1 fragment.

Released:
DOI: 10.2210/pdb5fzt/pdb
PDB entry 5fzt coloured by chain, front view.
PDB entry 5fzt coloured by chain, side view.
PDB entry 5fzt coloured by chain, top view.
Source organisms:
Primary publication:
LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex.
Zacharchenko T, Qian X, Goult BT, Jethwa D, Almeida TB, Ballestrem C, Critchley DR, Lowy DR, Barsukov IL
Structure 24 1130-41 (2016)
PMID: 27265849

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150645 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 32.57 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P26039 (Residues: 1359-1659; Coverage: 12%)
Gene names: Tln, Tln1
Structure domains:
Rho GTPase-activating protein 7 Chain: B
Molecule details ›
Chain: B
Length: 23 amino acids
Theoretical weight: 2.8 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q96QB1 (Residues: 904-926; Coverage: 2%)
Gene names: ARHGAP7, DLC1, KIAA1723, STARD12

Ligands and Environments

1 bound ligand:
Ligand MLI 2 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3121
Unit cell:
a: 73.26Å b: 73.26Å c: 111.82Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.177 0.231
Expression system: Not provided

Quick links

Citations

10 review citations

Integrin activation by talin, kindlin and mechanical forces.
Sun et al. (2019)
9 more

5 mentions without citation

Mechanotransduction in talin through the interaction of the R8 domain with DLC1.
Haining et al. (2018)
4 more