› 5g47

X-ray diffraction
2.45Å resolution

Structure of Gc glycoprotein from severe fever with thrombocytopenia syndrome virus in the trimeric postfusion conformation

Released:
DOI: 10.2210/pdb5g47/pdb
PDB entry 5g47 coloured by chain, front view.
PDB entry 5g47 coloured by chain, side view.
PDB entry 5g47 coloured by chain, top view.
Source organism: Severe fever with thrombocytopenia syndrome virus
Primary publication:
Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.
Halldorsson S, Behrens AJ, Harlos K, Huiskonen JT, Elliott RM, Crispin M, Brennan B, Bowden TA
Proc Natl Acad Sci U S A 113 7154-9 (2016)
PMID: 27325770

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycoprotein C Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 445 amino acids
Theoretical weight: 47.72 KDa
Source organism: Severe fever with thrombocytopenia syndrome virus
Expression system: Homo sapiens
UniProt:
  • Canonical: R4V2Q5 (Residues: 563-996; Coverage: 41%)
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: I212121
Unit cell:
a: 147.36Å b: 152.27Å c: 160.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.194 0.232
Expression system: Homo sapiens

Quick links

Citations

11 review citations

The HIV-1 envelope glycoprotein structure: nailing down a moving target.
Ward et al. (2017)
10 more

13 mentions without citation

Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure.
Hulswit et al. (2021)
12 more