› 5go4

X-ray diffraction
2.2Å resolution

Truncated mitofusin-1, nucleotide-free

Released:
DOI: 10.2210/pdb5go4/pdb
PDB entry 5go4 coloured by chain, front view.
PDB entry 5go4 coloured by chain, side view.
PDB entry 5go4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion.
Cao YL, Meng S, Chen Y, Feng JX, Gu DD, Yu B, Li YJ, Yang JY, Liao S, Chan DC, Gao S
Nature 542 372-376 (2017)
PMID: 28114303

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184884 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitofusin-1 Chain: A
Molecule details ›
Chain: A
Length: 433 amino acids
Theoretical weight: 48.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IWA4 (Residues: 1-365, 395-741; Coverage: 56%)
Gene name: MFN1
Sequence domains: Dynamin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 51.799Å b: 110.876Å c: 112.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.214
Expression system: Escherichia coli

Quick links

Citations

65 review citations

Mitochondrial dynamics: overview of molecular mechanisms.
Tilokani et al. (2018)
64 more

4 mentions without citation

Mitofusins: from mitochondria to fertility.
Zhao et al. (2022)
3 more