› 5go9

Electron Microscopy
4.4Å resolution

Cryo-EM structure of RyR2 in closed state

Released:
DOI: 10.2210/pdb5go9/pdb
PDB entry 5go9 coloured by chain, front view.
PDB entry 5go9 coloured by chain, side view.
PDB entry 5go9 coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2.
Peng W, Shen H, Wu J, Guo W, Pan X, Wang R, Chen SR, Yan N
Science 354 (2016)
PMID: 27708056
Related structures: EMD-9528

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165693 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RyR2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 4968 amino acids
Theoretical weight: 564.91 KDa
Source organism: Sus scrofa

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-9528

Quick links

Citations

35 review citations

The structural basis of ryanodine receptor ion channel function.
Meissner G. (2017)
34 more

14 mentions without citation

Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies.
Ogawa et al. (2021)
13 more