› 5goe

X-ray diffraction
1.8Å resolution

Truncated mitofusin-1, GDP-bound

Released:
DOI: 10.2210/pdb5goe/pdb
PDB entry 5goe coloured by chain, front view.
PDB entry 5goe coloured by chain, side view.
PDB entry 5goe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion.
Cao YL, Meng S, Chen Y, Feng JX, Gu DD, Yu B, Li YJ, Yang JY, Liao S, Chan DC, Gao S
Nature 542 372-376 (2017)
PMID: 28114303

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184884 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitofusin-1 Chain: A
Molecule details ›
Chain: A
Length: 422 amino acids
Theoretical weight: 47.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IWA4 (Residues: 1-741; Coverage: 56%)
Gene name: MFN1
Sequence domains: Dynamin family

Ligands and Environments

1 bound ligand:
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 70.42Å b: 72.91Å c: 94.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.204
Expression system: Escherichia coli

Quick links

Citations

64 review citations

Structural Insights into the Mechanism of Dynamin Superfamily Proteins.
Jimah et al. (2019)
63 more

9 mentions without citation

Mitochondrial quality control in the brain: The physiological and pathological roles.
Shen et al. (2022)
8 more