Function and Biology Details
Reactions catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131876 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Poly [ADP-ribose] polymerase tankyrase-1
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 18.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Ankyrin repeat-containing domain
Length: 169 amino acids
Theoretical weight: 18.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
O95271 (Residues: 799-957; Coverage: 12%)
Sequence domains:
Structure domains: Ankyrin repeat-containing domain
Ubiquitin carboxyl-terminal hydrolase 25
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Length: 10 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9UHP3 (Residues: 1046-1055; Coverage: 1%)
