› 5grw

X-ray diffraction
2.8Å resolution

Crystal structure of homo-specific diabody

Released:
DOI: 10.2210/pdb5grw/pdb
Model geometry
Fit model/data
PDB entry 5grw coloured by chain, front view.
PDB entry 5grw coloured by chain, side view.
PDB entry 5grw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of mono- and bi-specific diabodies and reduction of their structural flexibility by introduction of disulfide bridges at the Fv interface.
Kim JH, Song DH, Youn SJ, Kim JW, Cho G, Kim SC, Lee H, Jin MS, Lee JO
OpenAccess logo Sci Rep 6 34515 (2016)
PMID: 27682821

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235448 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
homo-specific diabody protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 249 amino acids
Theoretical weight: 26.9 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: C2
Unit cell:
a: 120.487Å b: 130.028Å c: 38.345Å
α: 90° β: 101.89° γ: 90°
R-values:
R R work R free
0.182 0.182 0.182
Expression system: Trichoplusia ni

Quick links

Citations

3 review citations

Perspectives on metals-based radioimmunotherapy (RIT): moving forward.
White et al. (2021)
2 more

1 mention without citation

Cross-linking disulfide bonds govern solution structures of diabodies.
Math et al. (2023)