› 5gt4

X-ray diffraction
1.83Å resolution

Crystal structure of the human vitamin D receptor ligand binding domain complexed with (1R,2S,3R,5Z,7E,14beta,17alpha)-2-cyanopropoxy-9,10-secocholesta-5,7,10-triene-1,3,25-triol

Released:
DOI: 10.2210/pdb5gt4/pdb
PDB entry 5gt4 coloured by chain, front view.
PDB entry 5gt4 coloured by chain, side view.
PDB entry 5gt4 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Takimoto-Kamimura M

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145848 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vitamin D3 receptor Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11473 (Residues: 118-423; Coverage: 60%)
Gene names: NR1I1, VDR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 2KB 1 x 2KB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 44.663Å b: 51.842Å c: 131.475Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.217
Expression system: Escherichia coli

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