› 5gva

X-ray diffraction
1.85Å resolution

WD40 domain of human AND-1

Released:
DOI: 10.2210/pdb5gva/pdb
PDB entry 5gva coloured by chain, front view.
PDB entry 5gva coloured by chain, side view.
PDB entry 5gva coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome.
Guan C, Li J, Sun D, Liu Y, Liang H
J Biol Chem 292 9627-9636 (2017)
PMID: 28381552

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131109 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat and HMG-box DNA-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 344 amino acids
Theoretical weight: 38.02 KDa
Source organism: Homo sapiens
Expression system: Trichoplasta
UniProt:
  • Canonical: O75717 (Residues: 1-330; Coverage: 29%)
Gene names: AND1, WDHD1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P43212
Unit cell:
a: 79.895Å b: 79.895Å c: 163.744Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.17 0.188
Expression system: Trichoplasta

Quick links

Citations

4 review citations

The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks.
van Schie et al. (2021)
3 more

3 mentions without citation

WD Repeat and HMG Box DNA Binding Protein 1: An Oncoprotein at the Hub of Tumorigenesis and a Novel Therapeutic Target.
Zhang et al. (2023)
2 more