› 5gvb

X-ray diffraction
2.75Å resolution

SepB domain of human AND-1

Released:
DOI: 10.2210/pdb5gvb/pdb
PDB entry 5gvb coloured by chain, front view.
PDB entry 5gvb coloured by chain, side view.
PDB entry 5gvb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome.
Guan C, Li J, Sun D, Liu Y, Liang H
J Biol Chem 292 9627-9636 (2017)
PMID: 28381552

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131110 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat and HMG-box DNA-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 442 amino acids
Theoretical weight: 50.51 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75717 (Residues: 416-850; Coverage: 39%)
Gene names: AND1, WDHD1
Sequence domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: F432
Unit cell:
a: 249.646Å b: 249.646Å c: 249.646Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.209 0.254
Expression system: Trichoplusia ni

Quick links

Citations

4 review citations

The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks.
van Schie et al. (2021)
3 more

5 mentions without citation

WD Repeat and HMG Box DNA Binding Protein 1: An Oncoprotein at the Hub of Tumorigenesis and a Novel Therapeutic Target.
Zhang et al. (2023)
4 more