Function and Biology Details
Reaction catalysed:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- DNA topoisomerase, type IA, central
- TOPRIM domain
- RecQ mediated genome instability protein 1, OB-fold domain
- RecQ mediated genome instability protein, N-terminal OB-fold domain superfamily
- RecQ mediated genome instability protein 1-like, N-terminal domain
- DNA topoisomerase, type IA, active site
- DNA topoisomerase, type IA, central region, subdomain 3
- DNA topoisomerase, type IA, DNA-binding domain
6 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132097 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA topoisomerase 3-beta-1
Molecule details ›
Chain: A
Length: 613 amino acids
Theoretical weight: 69.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Structure domains:
Length: 613 amino acids
Theoretical weight: 69.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O95985 (Residues: 1-612; Coverage: 71%)
Sequence domains:
Structure domains:
Tudor domain-containing protein 3
Molecule details ›
Chain: B
Length: 165 amino acids
Theoretical weight: 17.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: RMI1, N-terminal OB-fold domain
Length: 165 amino acids
Theoretical weight: 17.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9H7E2 (Residues: 1-68; Coverage: 10%)
Sequence domains: RMI1, N-terminal OB-fold domain
