› 5h3o

Electron Microscopy
3.5Å resolution

Structure of a eukaryotic cyclic nucleotide-gated channel

Released:
DOI: 10.2210/pdb5h3o/pdb
PDB entry 5h3o coloured by chain, front view.
PDB entry 5h3o coloured by chain, side view.
PDB entry 5h3o coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Structure of a eukaryotic cyclic-nucleotide-gated channel.
Li M, Zhou X, Wang S, Michailidis I, Gong Y, Su D, Li H, Li X, Yang J
Nature 542 60-65 (2017)
PMID: 28099415
Related structures: EMD-6656

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169922 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic nucleotide-gated cation channel Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 738 amino acids
Theoretical weight: 84.31 KDa
Source organism: Caenorhabditis elegans
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q03611 (Residues: 1-733; Coverage: 100%)
Gene names: ZC84.2, tax-4
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PCG 4 x PCG
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-6656
Expression system: Trichoplusia ni

Quick links

Citations

17 review citations

Cryo-EM in drug discovery: achievements, limitations and prospects.
Renaud et al. (2018)
16 more

18 mentions without citation

Structural insights into the mechanisms of CNBD channel function.
James et al. (2018)
17 more